Secretory immunoglobulin A: well beyond immune exclusion at mucosal surfaces.

Détails

ID Serval
serval:BIB_407F9DD78498
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Secretory immunoglobulin A: well beyond immune exclusion at mucosal surfaces.
Périodique
Immunopharmacology and Immunotoxicology
Auteur(s)
Corthésy Blaise
ISSN
1532-2513[electronic]
Statut éditorial
Publié
Date de publication
2009
Volume
31
Numéro
2
Pages
174-179
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish
Résumé
At mucosal surfaces, secretory IgA (SIgA) antibodies serve as the first line of defense against microorganisms through a mechanism called immune exclusion that prevents interaction of neutralized antigens with the epithelium. In addition, SIgA plays a role in the immune balance of the epithelial barrier through selective adhesion to M cells in intestinal Peyer's patches. This mediates the transepithelial retro-transport of the antibody and associated antigens from the intestinal lumen to underlying gut-associated organized lymphoid tissue. In Peyer's patches, SIgA-based immune complexes are internalized by underlying antigen-presenting cells, leaving the antigen with masked epitopes, a form that limits the risk of overwhelming the local immune protection system with danger signals. This translates into the onset of mucosal and systemic responses associated with production of anti-inflammatory cytokines and limited activation of antigen-presenting cells. In the gastrointestinal tract, SIgA exhibits thus properties of a neutralizing agent (immune exclusion) and of an immunopotentiator inducing effector immune responses in a noninflammatory context favorable to preserve local homeostasis.
Pubmed
Web of science
Création de la notice
26/01/2010 16:55
Dernière modification de la notice
03/03/2018 16:28
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