Primary mucosa-associated lymphoid tissue lymphoma of the gallbladder: report of a case harboring API2/MALT1 gene fusion.

Details

Serval ID
serval:BIB_406D727FDB0A
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Title
Primary mucosa-associated lymphoid tissue lymphoma of the gallbladder: report of a case harboring API2/MALT1 gene fusion.
Journal
Human Pathology
Author(s)
Bisig B., Copie-Bergman C., Baia M., Gaulard P., Delbecque K., Fassotte M.F., Boniver J., de Leval L.
ISSN
1532-8392[electronic], 0046-8177[linking]
Publication state
Published
Issued date
2009
Volume
40
Number
10
Pages
1504-1509
Language
english
Abstract
The genetic alterations underlying extranodal marginal zone B-cell lymphomas of mucosa-associated lymphoid tissue type are heterogeneous and show variation according to the tumor site. Here, we report a case of mucosa-associated lymphoid tissue lymphoma of the gallbladder with genetic characterization. This lymphoma, diagnosed in a 75-year-old woman who underwent cholecystectomy for suspected acute cholecystitis, presented as diffuse thickening of the gallbladder wall. The morphology was typical of mucosa-associated lymphoid tissue lymphoma, and by immunophenotype, the tumor cells were CD20+ CD5- CD10- CD23- CD43- BCL6- BCL2+ IgM+ IgD- lambda+, with moderate nuclear expression of BCL10. Interphase fluorescence in situ hybridization analysis on paraffin sections, using a fusion probe for API2/MALT1, demonstrated 2 fusion signals in most nuclei, bringing the first documentation of a t(11;18)(q21;q21) in this exceptional primary disease location.
Keywords
Aged, Cholecystectomy, Female, Gallbladder Neoplasms/genetics, Gallbladder Neoplasms/immunology, Humans, Immunohistochemistry, Immunophenotyping, In Situ Hybridization, Fluorescence, Lymphoma, B-Cell, Marginal Zone/genetics, Lymphoma, B-Cell, Marginal Zone/immunology, Oncogene Proteins, Fusion/genetics
Pubmed
Create date
22/10/2010 14:53
Last modification date
20/08/2019 14:38
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