Glial cell line-derived neurotrophic factor (GDNF), a new neurotrophic factor for motoneurones
Details
Serval ID
serval:BIB_3F908118C242
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Glial cell line-derived neurotrophic factor (GDNF), a new neurotrophic factor for motoneurones
Journal
Neuroreport
ISSN
0959-4965 (Print)
Publication state
Published
Issued date
12/1994
Volume
6
Number
1
Pages
113-8
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Dec 30
Research Support, Non-U.S. Gov't --- Old month value: Dec 30
Abstract
Glial cell line-derived neurotrophic factor (GDNF) has been postulated to be a specific dopaminergic neurotrophic factor since it selectively enhances the survival of dopaminergic neurones in vitro. We report here that GDNF can also act as a neurotrophic factor for motoneurones. GDNF released by GDNF-transfected BHK cells increases the activity of choline acetyltransferase (ChAT) in cultures from embryonic rat ventral mesencephalon containing cholinergic neurones from cranial motor nuclei and in cultured spinal motoneurones. Furthermore, local application of polymer-encapsulated BHK cells releasing GDNF to transected facial nerve in newborn rats diminishes the death of motoneurones normally occurring after axotomy in the neonatal period. The present results indicate that GDNF may have a therapeutic potential in human motoneurone diseases such as amyotrophic lateral sclerosis.
Keywords
Animals
Base Sequence
Brain-Derived Neurotrophic Factor
Cells, Cultured
Choline O-Acetyltransferase/metabolism
Ciliary Neurotrophic Factor
Drug Synergism
Glial Cell Line-Derived Neurotrophic Factor
Mesencephalon/cytology/enzymology
Molecular Sequence Data
Motor Neurons/*drug effects
Nerve Growth Factors/*pharmacology
Nerve Tissue Proteins/genetics/*pharmacology
Parasympathetic Nervous System/cytology
Rats
Spinal Cord/cytology
Pubmed
Web of science
Create date
28/01/2008 9:44
Last modification date
20/08/2019 14:36