Cancer du poumon à petites cellules : prise en charge et nouveautés [Small-cell lung cancer: management and novelties]

Details

Serval ID
serval:BIB_3F2FC3093CB5
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Cancer du poumon à petites cellules : prise en charge et nouveautés [Small-cell lung cancer: management and novelties]
Journal
Revue medicale suisse
Author(s)
Abdelhamid K., Kakourou A., Degrauwe N., Nikolopoulou A., Bouchaab H., Peters S., Nguyen-Ngoc T., Mederos N.
ISSN
1660-9379 (Print)
ISSN-L
1660-9379
Publication state
Published
Issued date
27/05/2020
Peer-reviewed
Oui
Volume
16
Number
695
Pages
1079-1085
Language
french
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Small cell lung cancer is a recalcitrant malignancy with 5-year survival rates of less than 20%. In the majority of cases, patients have metastatic disease at diagnosis despite the new screening method by low-dose CT-scan. The high throughput sequencing has deepened our understanding of its biology. While the treatment of localized disease has changed little, the arrival of immune checkpoint inhibitors have revolutionized the management of extensive disease. At the same time, new strategies involving certain potential genetic targets are being analyzed on a large scale that could become valuable therapeutic alternatives in the future. Radiation therapy remains a very useful therapeutic modality in all stages of the disease. This article aims to review the epidemiology, molecular pathology, management and innovative therapies in small-cell lung cancer.
Keywords
Humans, Lung Neoplasms/drug therapy, Lung Neoplasms/radiotherapy, Lung Neoplasms/therapy, Small Cell Lung Carcinoma/drug therapy, Small Cell Lung Carcinoma/radiotherapy, Small Cell Lung Carcinoma/therapy, Survival Rate
Pubmed
Create date
10/06/2020 22:10
Last modification date
21/11/2020 7:26
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