Neuropathologie et pathologie moléculaire des gliomes [Neuropathology and molecular pathology of gliomas]

Details

Serval ID
serval:BIB_3F1562FBA09E
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Neuropathologie et pathologie moléculaire des gliomes [Neuropathology and molecular pathology of gliomas]
Journal
Revue Médicale Suisse
Author(s)
Janzer R.C.
ISSN
1660-9379 ([print])
1660-9379 ([linking])
ISSN-L
1660-9379
Publication state
Published
Issued date
2009
Volume
5
Number
211
Pages
1501-1504
Language
french
Abstract
Gliomas are the most frequent primary brain tumours. The WHO classification is essentially based on histological and immunohistochemical criteria. More recently multiple cytogenetic and molecular alterations associated with initiation and progression have been shown and the genetic profiles of tumour entities have been incorporated in the WHO classifiacation. Molecular testing of the MGMT promotor methylation in glioblastoma, predictive for the response to combined radio-/chimiothérapie, and the LOH 1p/19q in oligodendroglial tumours, as prognostic factor supplements the histopathological diagnosis. In the near futur array-based profiling techniques will contribute to a refinement of glioma classification and identify targets for more individualized glioma therapies.
Keywords
Central Nervous System Neoplasms/pathology, Glioma/pathology, Humans
Pubmed
Create date
19/10/2010 7:29
Last modification date
20/08/2019 13:36
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