Modulation of phosphorylation of neuronal cytoskeletal proteins by neuronal depolarization.

Details

Serval ID
serval:BIB_3ECC051D4CE7
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Modulation of phosphorylation of neuronal cytoskeletal proteins by neuronal depolarization.
Journal
Cellular and Molecular Neurobiology
Author(s)
Mata M., Honegger P., Fink D.J.
ISSN
0272-4340 (Print)
ISSN-L
0272-4340
Publication state
Published
Issued date
1997
Volume
17
Number
1
Pages
129-140
Language
english
Abstract
1. The neuronal cytoskeletal protein tau and the carboxy tails of cytoskeletal proteins neurofilament-M (NF-M) and neurofilament-H (NF-H) are phosphorylated on serine residues by the cyclin-dependent kinase cdk-5. 2. In aggregating neuronal-glial cultures we show that veratridine-mediated cation influx causes dephosphorylation of tau, NF-M and NF-H. Dephosphorylation was blocked specifically by cyclosporine A but not by okadiac acid at concentrations up to 200 nM. 3. These results suggest that veratridine-triggered cation influx causes activation of PP-2B (calcineurin) leading to dephosphorylation of these cytoskeletal proteins.
Keywords
Animals, Blotting, Western, Cells, Cultured, Cytoskeletal Proteins/drug effects, Cytoskeletal Proteins/metabolism, Embryo, Mammalian, Nerve Tissue Proteins/drug effects, Nerve Tissue Proteins/metabolism, Neurofilament Proteins/drug effects, Neurofilament Proteins/metabolism, Neuromuscular Depolarizing Agents/pharmacology, Phosphoric Monoester Hydrolases/drug effects, Phosphoric Monoester Hydrolases/physiology, Phosphorylation/drug effects, Rats, Sodium/metabolism, Veratridine/pharmacology, tau Proteins/metabolism
Pubmed
Web of science
Create date
24/01/2008 13:11
Last modification date
20/08/2019 13:35
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