The alpha 1a and alpha 1b-adrenergic receptor subtypes: molecular mechanisms of receptor activation and of drug action.
Details
Serval ID
serval:BIB_3EC9D9C38883
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
The alpha 1a and alpha 1b-adrenergic receptor subtypes: molecular mechanisms of receptor activation and of drug action.
Journal
Pharmaceutica Acta Helvetiae
ISSN
0031-6865 (Print)
ISSN-L
0031-6865
Publication state
Published
Issued date
2000
Volume
74
Number
2-3
Pages
173-179
Language
english
Abstract
In this chapter we summarize some aspects of the structure-functional relationship of the alpha 1a and alpha 1b-adrenergic receptor subtypes related to the receptor activation process as well as the effect of different alpha-blockers on the constitutive activity of the receptor. Molecular modeling of the alpha 1a and alpha 1b-adrenergic receptor subtypes and computational simulation of receptor dynamics were useful to interpret the experimental findings derived from site directed mutagenesis studies.
Keywords
Animals, Humans, Receptors, Adrenergic, alpha-1/chemistry, Receptors, Adrenergic, alpha-1/drug effects
Pubmed
Create date
24/01/2008 12:05
Last modification date
20/08/2019 14:35
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