Synthesis and transport of creatine in the CNS: importance for cerebral functions.

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Serval ID
serval:BIB_3E2EFAC6855E
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Synthesis and transport of creatine in the CNS: importance for cerebral functions.
Journal
Journal of Neurochemistry
Author(s)
Béard E., Braissant O.
ISSN
1471-4159[electronic], 0022-3042[linking]
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
115
Pages
297-313
Language
english
Notes
Publication types: JOURNAL ARTICLE
Abstract
J. Neurochem. (2010) 10.1111/j.1471-4159.2010.06935.x Abstract Apart of its well known function of 'energetic buffer' through the creatine/phosphocreatine/creatine kinase system allowing the regeneration of ATP, creatine has been recently suggested as a potential neuromodulator of even true neurotransmitter. Moreover, the recent discovery of primary creatine deficiency syndromes, due to deficiencies in l-arginine : glycine amidinotransferase or guanidinoacetate methyltransferase (the two enzymes allowing creatine synthesis) or in the creatine transporter, has shed new light on creatine synthesis, metabolism and transport, in particular in CNS which appears as the main tissue affected by these creatine deficiencies. Recent data suggest that creatine can cross blood-brain barrier but only with a poor efficiency, and that the brain must ensure parts of its needs in creatine by its own endogenous synthesis. Finally, the recent years have demonstrated the interest to use creatine as a neuroprotective agent in a growing number of neurodegenerative diseases, including Parkinson's and Huntington's diseases. This article aims at reviewing the latest data on creatine metabolism and transport in the brain, in relation to creatine deficiencies and to the potential use of creatine as neuroprotective molecule. Emphasis is also given to the importance of creatine for cerebral function.
Pubmed
Web of science
Open Access
Yes
Create date
17/08/2010 9:56
Last modification date
20/08/2019 13:34
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