Caspase substrates and neurodegenerative diseases.

Details

Serval ID
serval:BIB_3E0AF6CE2126
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Caspase substrates and neurodegenerative diseases.
Journal
Brain Research Bulletin
Author(s)
Bulat N., Widmann C.
ISSN
1873-2747[electronic]
Publication state
Published
Issued date
2009
Volume
80
Number
4-5
Pages
251-267
Language
english
Abstract
Apoptosis is induced by the cleavage of a subset of cellular proteins by proteases of the caspase family. Numerous (hundreds) caspase substrates have been described but only for a few of them is the function of their cleavage by caspases well understood. In this review, apoptosis and caspases will first be introduced. The main focus will then be directed to the caspase substrates, the actual "workers" doing the job of mediating and regulating the apoptotic process. The caspase substrates whose functions upon cleavage have been carefully investigated and those that are potentially involved in neurodegenerative diseases will be discussed in detail.
Keywords
Neurodegenerative diseases, Caspases, Substrates, Apoptosis, Survival, Huntingtin, APP, Tau, Preselinins, RasGAP, Rb, PARP, Amyloid Precursor Protein, N-Terminal Fragments, Alzheimers-Disease, Cell-Death, Huntingtons-Disease, Mutant Huntingtin, Wild-Type, Mouse Model, In-Vivo, Poly(Adp-Ribose) Polymerase
Pubmed
Web of science
Create date
12/11/2009 16:44
Last modification date
20/08/2019 13:34
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