Caspase substrates and neurodegenerative diseases.

Détails

ID Serval
serval:BIB_3E0AF6CE2126
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Caspase substrates and neurodegenerative diseases.
Périodique
Brain Research Bulletin
Auteur⸱e⸱s
Bulat N., Widmann C.
ISSN
1873-2747[electronic]
Statut éditorial
Publié
Date de publication
2009
Volume
80
Numéro
4-5
Pages
251-267
Langue
anglais
Résumé
Apoptosis is induced by the cleavage of a subset of cellular proteins by proteases of the caspase family. Numerous (hundreds) caspase substrates have been described but only for a few of them is the function of their cleavage by caspases well understood. In this review, apoptosis and caspases will first be introduced. The main focus will then be directed to the caspase substrates, the actual "workers" doing the job of mediating and regulating the apoptotic process. The caspase substrates whose functions upon cleavage have been carefully investigated and those that are potentially involved in neurodegenerative diseases will be discussed in detail.
Mots-clé
Neurodegenerative diseases, Caspases, Substrates, Apoptosis, Survival, Huntingtin, APP, Tau, Preselinins, RasGAP, Rb, PARP, Amyloid Precursor Protein, N-Terminal Fragments, Alzheimers-Disease, Cell-Death, Huntingtons-Disease, Mutant Huntingtin, Wild-Type, Mouse Model, In-Vivo, Poly(Adp-Ribose) Polymerase
Pubmed
Web of science
Création de la notice
12/11/2009 16:44
Dernière modification de la notice
20/08/2019 13:34
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