Inter-organ communication: a gatekeeper for metabolic health.

Details

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State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_3D85056E88C8
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Inter-organ communication: a gatekeeper for metabolic health.
Journal
EMBO reports
Author(s)
Castillo-Armengol J., Fajas L., Lopez-Mejia I.C.
ISSN
1469-3178 (Electronic)
ISSN-L
1469-221X
Publication state
Published
Issued date
09/2019
Peer-reviewed
Oui
Volume
20
Number
9
Pages
e47903
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
Multidirectional interactions between metabolic organs in the periphery and the central nervous system have evolved concomitantly with multicellular organisms to maintain whole-body energy homeostasis and ensure the organism's adaptation to external cues. These interactions are altered in pathological conditions such as obesity and type 2 diabetes. Bioactive peptides and proteins, such as hormones and cytokines, produced by both peripheral organs and the central nervous system, are key messengers in this inter-organ communication. Despite the early discovery of the first hormones more than 100 years ago, recent studies taking advantage of novel technologies have shed light on the multiple ways used by cells in the body to communicate and maintain energy balance. This review briefly summarizes well-established concepts and focuses on recent advances describing how specific proteins and peptides mediate the crosstalk between gut, brain, and other peripheral metabolic organs in order to maintain energy homeostasis. Additionally, this review outlines how the improved knowledge about these inter-organ networks is helping us to redefine therapeutic strategies in an effort to promote healthy living and fight metabolic disorders and other diseases.
Keywords
Animals, Diabetes Mellitus, Type 2/metabolism, Energy Metabolism/genetics, Energy Metabolism/physiology, Homeostasis/genetics, Homeostasis/physiology, Humans, Models, Biological, Obesity/metabolism, energy homeostasis, inter-organ communication, metabolism, obesity
Pubmed
Open Access
Yes
Create date
30/08/2019 23:14
Last modification date
01/08/2020 5:19
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