Determination of meprobamate in human plasma, urine, and hair by gas chromatography and electron impact mass spectrometry.
Details
Serval ID
serval:BIB_3CFC7925B916
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Determination of meprobamate in human plasma, urine, and hair by gas chromatography and electron impact mass spectrometry.
Journal
Journal of Analytical Toxicology
ISSN
0146-4760[print], 0146-4760[linking]
Publication state
Published
Issued date
1993
Volume
17
Number
7
Pages
408-410
Language
english
Abstract
A sensitive and specific quantitative assay for the determination of meprobamate in human fluids and hair is described. Meprobamate and an internal standard, vinylbarbital, are isolated by acid extraction and methylated by derivatization. The final extract is separated on a 12-m capillary column HP-1 and drugs are detected by selected ion monitoring at m/z 162 and m/z 182 for meprobamate and the internal standard, respectively. Applications in forensic science, particularly for hair analysis, are presented.
Keywords
Chromatography, Gas/methods, Hair/chemistry, Humans, Mass Spectrometry/methods, Meprobamate/analysis, Meprobamate/blood
Pubmed
Create date
18/10/2010 15:03
Last modification date
20/08/2019 14:33
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