Determination of meprobamate in human plasma, urine, and hair by gas chromatography and electron impact mass spectrometry.

Détails

ID Serval
serval:BIB_3CFC7925B916
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Determination of meprobamate in human plasma, urine, and hair by gas chromatography and electron impact mass spectrometry.
Périodique
Journal of Analytical Toxicology
Auteur⸱e⸱s
Kintz P., Mangin P.
ISSN
0146-4760[print], 0146-4760[linking]
Statut éditorial
Publié
Date de publication
1993
Volume
17
Numéro
7
Pages
408-410
Langue
anglais
Résumé
A sensitive and specific quantitative assay for the determination of meprobamate in human fluids and hair is described. Meprobamate and an internal standard, vinylbarbital, are isolated by acid extraction and methylated by derivatization. The final extract is separated on a 12-m capillary column HP-1 and drugs are detected by selected ion monitoring at m/z 162 and m/z 182 for meprobamate and the internal standard, respectively. Applications in forensic science, particularly for hair analysis, are presented.
Mots-clé
Chromatography, Gas/methods, Hair/chemistry, Humans, Mass Spectrometry/methods, Meprobamate/analysis, Meprobamate/blood
Pubmed
Création de la notice
18/10/2010 14:03
Dernière modification de la notice
20/08/2019 13:33
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