BAFF and the regulation of B cell survival.

Details

Serval ID
serval:BIB_3C6834043B43
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
BAFF and the regulation of B cell survival.
Journal
Immunology Letters
Author(s)
Schneider P., Tschopp J.
ISSN
0165-2478 (Print)
ISSN-L
0165-2478
Publication state
Published
Issued date
2003
Volume
88
Number
1
Pages
57-62
Language
english
Abstract
The TNF family member BAFF is a fundamental survival factor for B cells. BAFF binds to three receptors, only one of which, BAFF-R, does not cross-react with the BAFF-related ligand APRIL. The survival function of BAFF on B cells is mediated mainly by BAFF-R and is particularly effective in transitional B cells. BAFF depletion leads to a considerable decrease in mature B cells, without apparent effect on B cell genesis. Consistently, BAFF overexpression results in an expanded B cell compartment and autoimmunity in mice. Elevated amounts of BAFF can be found in the serum of patients suffering from autoimmune diseases. The BAFF system is a promising target for the treatment of autoimmune diseases.
Keywords
Animals, Autoimmunity, B-Cell Activating Factor, B-Cell Activation Factor Receptor, B-Lymphocyte Subsets/cytology, B-Lymphocyte Subsets/immunology, Cell Differentiation, Cell Survival, Humans, Immune Tolerance, Membrane Proteins/genetics, Membrane Proteins/immunology, Mice, Receptors, Tumor Necrosis Factor/chemistry, Receptors, Tumor Necrosis Factor/genetics, Signal Transduction, Tumor Necrosis Factor Ligand Superfamily Member 13, Tumor Necrosis Factor-alpha/immunology, Tumor Necrosis Factor-alpha/physiology
Pubmed
Web of science
Create date
24/01/2008 15:19
Last modification date
20/08/2019 13:32
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