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BAFF and the regulation of B cell survival.
The TNF family member BAFF is a fundamental survival factor for B cells. BAFF binds to three receptors, only one of which, BAFF-R, does not cross-react with the BAFF-related ligand APRIL. The survival function of BAFF on B cells is mediated mainly by BAFF-R and is particularly effective in transitional B cells. BAFF depletion leads to a considerable decrease in mature B cells, without apparent effect on B cell genesis. Consistently, BAFF overexpression results in an expanded B cell compartment and autoimmunity in mice. Elevated amounts of BAFF can be found in the serum of patients suffering from autoimmune diseases. The BAFF system is a promising target for the treatment of autoimmune diseases.
Animals, Autoimmunity, B-Cell Activating Factor, B-Cell Activation Factor Receptor, B-Lymphocyte Subsets/cytology, B-Lymphocyte Subsets/immunology, Cell Differentiation, Cell Survival, Humans, Immune Tolerance, Membrane Proteins/genetics, Membrane Proteins/immunology, Mice, Receptors, Tumor Necrosis Factor/chemistry, Receptors, Tumor Necrosis Factor/genetics, Signal Transduction, Tumor Necrosis Factor Ligand Superfamily Member 13, Tumor Necrosis Factor-alpha/immunology, Tumor Necrosis Factor-alpha/physiology
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