Long-term circulatory and renal consequences of intrauterine growth restriction.

Details

Serval ID
serval:BIB_3B461EF7AC25
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Long-term circulatory and renal consequences of intrauterine growth restriction.
Journal
Acta Paediatrica
Author(s)
Simeoni U., Zetterström R.
ISSN
0803-5253 (Print)
ISSN-L
0803-5253
Publication state
Published
Issued date
2005
Peer-reviewed
Oui
Volume
94
Number
7
Pages
819-824
Language
english
Notes
Publication types: Journal Article ; Review Publication Status: ppublish
Abstract
Intrauterine growth restriction (IUGR) and probably also early postnatal altered nutrition in very-low-birthweight babies may, in the long term, be followed by the various disorders that are included in the metabolic syndrome. This discovery has raised a new paradigm about the background to cardiovascular disease, arterial hypertension, obesity, type 2 diabetes and dyslipidaemic disorders that play a prominent role in shortening human life. In this review article, present knowledge about the background to renal dysfunction as seen in IUGR is summarized. The way in which arterial hypertension and cardiovascular dysfunction may be programmed in IUGR is also speculated.
CONCLUSION: During the last decade, knowledge of the long-term consequences of IUGR has increased at a very rapid rate. At present, it is most important not only to develop efficient methods of preventing and diagnosing IUGR, but to work out follow-up and treatment programmes for the control of the disorders which may follow this condition. Proper postnatal feeding and infant growth may be essential for long-term outcome.
Keywords
Animals, Cardiovascular Diseases/etiology, Fetal Growth Retardation/physiopathology, Glomerular Filtration Rate, Glucocorticoids/physiology, Humans, Hypertension/etiology, Infant, Newborn, Infant, Small for Gestational Age, Infant, Very Low Birth Weight, Kidney/embryology, Kidney Diseases/etiology, Nephrons/embryology, Renin-Angiotensin System/physiology, Stress, Physiological/physiopathology, Time Factors
Pubmed
Web of science
Create date
22/02/2015 11:25
Last modification date
20/08/2019 13:31
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