Coordinated effects of sequence variation on DNA binding, chromatin structure, and transcription.

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State: Public
Version: Author's accepted manuscript
Serval ID
serval:BIB_3B38B04B8D47
Type
Article: article from journal or magazin.
Collection
Publications
Title
Coordinated effects of sequence variation on DNA binding, chromatin structure, and transcription.
Journal
Science
Author(s)
Kilpinen H., Waszak S.M., Gschwind A.R., Raghav S.K., Witwicki R.M., Orioli A., Migliavacca E., Wiederkehr M., Gutierrez-Arcelus M., Panousis N.I., Yurovsky A., Lappalainen T., Romano-Palumbo L., Planchon A., Bielser D., Bryois J., Padioleau I., Udin G., Thurnheer S., Hacker D., Core L.J., Lis J.T., Hernandez N., Reymond A., Deplancke B., Dermitzakis E.T.
ISSN
1095-9203 (Electronic)
ISSN-L
0036-8075
Publication state
Published
Issued date
2013
Volume
342
Number
6159
Pages
744-747
Language
english
Abstract
DNA sequence variation has been associated with quantitative changes in molecular phenotypes such as gene expression, but its impact on chromatin states is poorly characterized. To understand the interplay between chromatin and genetic control of gene regulation, we quantified allelic variability in transcription factor binding, histone modifications, and gene expression within humans. We found abundant allelic specificity in chromatin and extensive local, short-range, and long-range allelic coordination among the studied molecular phenotypes. We observed genetic influence on most of these phenotypes, with histone modifications exhibiting strong context-dependent behavior. Our results implicate transcription factors as primary mediators of sequence-specific regulation of gene expression programs, with histone modifications frequently reflecting the primary regulatory event.
Pubmed
Web of science
Create date
28/11/2013 10:43
Last modification date
20/08/2019 14:31
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