New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.

Lu, Y.; Day, F.R.; Gustafsson, S.; Buchkovich, M.L.; Na, J.; Bataille, V.; Cousminer, D.L.; Dastani, Z.; Drong, A.W.; Esko, T.; Evans, D.M.; Falchi, M.; Feitosa, M.F.; Ferreira, T.; Hedman, Å.K.; Haring, R.; Hysi, P.G.; Iles, M.M.; Justice, A.E.; Kanoni, S.; Lagou, V.; Li, R.; Li, X.; Locke, A.; Lu, C.; Mägi, R.; Perry, J.R.; Pers, T.H.; Qi, Q.; Sanna, M.; Schmidt, E.M.; Scott, W.R.; Shungin, D.; Teumer, A.; Vinkhuyzen, A.A.; Walker, R.W.; Westra, H.J.; Zhang, M.; Zhang, W.; Zhao, J.H.; Zhu, Z.; Afzal, U.; Ahluwalia, T.S.; Bakker, S.J.; Bellis, C.; Bonnefond, A.; Borodulin, K.; Buchman, A.S.; Cederholm, T.; Choh, A.C.; Choi, H.J.; Curran, J.E.; de Groot, L.C.; De Jager, P.L.; Dhonukshe-Rutten, R.A.; Enneman, A.W.; Eury, E.; Evans, D.S.; Forsen, T.; Friedrich, N.; Fumeron, F.; Garcia, M.E.; Gärtner, S.; Han, B.G.; Havulinna, A.S.; Hayward, C.; Hernandez, D.; Hillege, H.; Ittermann, T.; Kent, J.W.; Kolcic, I.; Laatikainen, T.; Lahti, J.; Mateo Leach, I.; Lee, C.G.; Lee, J.Y.; Liu, T.; Liu, Y.; Lobbens, S.; Loh, M.; Lyytikäinen, L.P.; Medina-Gomez, C.; Michaëlsson, K.; Nalls, M.A.; Nielson, C.M.; Oozageer, L.; Pascoe, L.; Paternoster, L.; Polašek, O.; Ripatti, S.; Sarzynski, M.A.; Shin, C.S.; Narančić, N.S.; Spira, D.; Srikanth, P.; Steinhagen-Thiessen, E.; Sung, Y.J.; Swart, K.M.; Taittonen, L.; Tanaka, T.; Tikkanen, E.; van der Velde, N.; van Schoor, N.M.; Verweij, N.; Wright, A.F.; Yu, L.; Zmuda, J.M.; Eklund, N.; Forrester, T.; Grarup, N.; Jackson, A.U.; Kristiansson, K.; Kuulasmaa, T.; Kuusisto, J.; Lichtner, P.; Luan, J.; Mahajan, A.; Männistö, S.; Palmer, C.D.; Ried, J.S.; Scott, R.A.; Stancáková, A.; Wagner, P.J.; Demirkan, A.; Döring, A.; Gudnason, V.; Kiel, D.P.; Kühnel, B.; Mangino, M.; Mcknight, B.; Menni, C.; O'Connell, J.R.; Oostra, B.A.; Shuldiner, A.R.; Song, K.; Vandenput, L.; van Duijn, C.M.; Vollenweider, P.; White, C.C.; Boehnke, M.; Boettcher, Y.; Cooper, R.S.; Forouhi, N.G.; Gieger, C.; Grallert, H.; Hingorani, A.; Jørgensen, T.; Jousilahti, P.; Kivimaki, M.; Kumari, M.; Laakso, M.; Langenberg, C.; Linneberg, A.; Luke, A.; Mckenzie, C.A.; Palotie, A.; Pedersen, O.; Peters, A.; Strauch, K.; Tayo, B.O.; Wareham, N.J.; Bennett, D.A.; Bertram, L.; Blangero, J.; Blüher, M.; Bouchard, C.; Campbell, H.; Cho, N.H.; Cummings, S.R.; Czerwinski, S.A.; Demuth, I.; Eckardt, R.; Eriksson, J.G.; Ferrucci, L.; Franco, O.H.; Froguel, P.; Gansevoort, R.T.; Hansen, T.; Harris, T.B.; Hastie, N.; Heliövaara, M.; Hofman, A.; Jordan, J.M.; Jula, A.; Kähönen, M.; Kajantie, E.; Knekt, P.B.; Koskinen, S.; Kovacs, P.; Lehtimäki, T.; Lind, L.; Liu, Y.; Orwoll, E.S.; Osmond, C.; Perola, M.; Pérusse, L.; Raitakari, O.T.; Rankinen, T.; Rao, D.C.; Rice, T.K.; Rivadeneira, F.; Rudan, I.; Salomaa, V.; Sørensen, T.I.; Stumvoll, M.; Tönjes, A.; Towne, B.; Tranah, G.J.; Tremblay, A.; Uitterlinden, A.G.; van der Harst, P.; Vartiainen, E.; Viikari, J.S.; Vitart, V.; Vohl, M.C.; Völzke, H.; Walker, M.; Wallaschofski, H.; Wild, S.; Wilson, J.F.; Yengo, L.; Bishop, D.T.; Borecki, I.B.; Chambers, J.C.; Cupples, L.A.; Dehghan, A.; Deloukas, P.; Fatemifar, G.; Fox, C.; Furey, T.S.; Franke, L.; Han, J.; Hunter, D.J.; Karjalainen, J.; Karpe, F.; Kaplan, R.C.; Kooner, J.S.; McCarthy, M.I.; Murabito, J.M.; Morris, A.P.; Bishop, J.A.; North, K.E.; Ohlsson, C.; Ong, K.K.; Prokopenko, I.; Richards, J.B.; Schadt, E.E.; Spector, T.D.; Widén, E.; Willer, C.J.; Yang, J.; Ingelsson, E.; Mohlke, K.L.; Hirschhorn, J.N.; Pospisilik, J.A.; Zillikens, M.C.; Lindgren, C.; Kilpeläinen, T.O.; Loos, R.J.

doi:10.1038/ncomms10495

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.

Details

Download: BIB_3AD8785589CA.P001.pdf (1995.50 [Ko])
State: Public
Version: author

Serval ID

serval:BIB_3AD8785589CA

Type

Article: article from journal or magazin.

Collection

Publications

Institution

UNIL/CHUV

Title

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.

Journal

Nature Communications

Author(s)

Lu Y., Day F.R., Gustafsson S., Buchkovich M.L., Na J., Bataille V., Cousminer D.L., Dastani Z., Drong A.W., Esko T., Evans D.M., Falchi M., Feitosa M.F., Ferreira T., Hedman Å.K., Haring R., Hysi P.G., Iles M.M., Justice A.E., Kanoni S., Lagou V., Li R., Li X., Locke A., Lu C., Mägi R., Perry J.R., Pers T.H., Qi Q., Sanna M., Schmidt E.M., Scott W.R., Shungin D., Teumer A., Vinkhuyzen A.A., Walker R.W., Westra H.J., Zhang M., Zhang W., Zhao J.H., Zhu Z., Afzal U., Ahluwalia T.S., Bakker S.J., Bellis C., Bonnefond A., Borodulin K., Buchman A.S., Cederholm T., Choh A.C., Choi H.J., Curran J.E., de Groot L.C., De Jager P.L., Dhonukshe-Rutten R.A., Enneman A.W., Eury E., Evans D.S., Forsen T., Friedrich N., Fumeron F., Garcia M.E., Gärtner S., Han B.G., Havulinna A.S., Hayward C., Hernandez D., Hillege H., Ittermann T., Kent J.W., Kolcic I., Laatikainen T., Lahti J., Mateo Leach I., Lee C.G., Lee J.Y., Liu T., Liu Y., Lobbens S., Loh M., Lyytikäinen L.P., Medina-Gomez C., Michaëlsson K., Nalls M.A., Nielson C.M., Oozageer L., Pascoe L., Paternoster L., Polašek O., Ripatti S., Sarzynski M.A., Shin C.S., Narančić N.S., Spira D., Srikanth P., Steinhagen-Thiessen E., Sung Y.J., Swart K.M., Taittonen L., Tanaka T., Tikkanen E., van der Velde N., van Schoor N.M., Verweij N., Wright A.F., Yu L., Zmuda J.M., Eklund N., Forrester T., Grarup N., Jackson A.U., Kristiansson K., Kuulasmaa T., Kuusisto J., Lichtner P., Luan J., Mahajan A., Männistö S., Palmer C.D., Ried J.S., Scott R.A., Stancáková A., Wagner P.J., Demirkan A., Döring A., Gudnason V., Kiel D.P., Kühnel B., Mangino M., Mcknight B., Menni C., O'Connell J.R., Oostra B.A., Shuldiner A.R., Song K., Vandenput L., van Duijn C.M., Vollenweider P., White C.C., Boehnke M., Boettcher Y., Cooper R.S., Forouhi N.G., Gieger C., Grallert H., Hingorani A., Jørgensen T., Jousilahti P., Kivimaki M., Kumari M., Laakso M., Langenberg C., Linneberg A., Luke A., Mckenzie C.A., Palotie A., Pedersen O., Peters A., Strauch K., Tayo B.O., Wareham N.J., Bennett D.A., Bertram L., Blangero J., Blüher M., Bouchard C., Campbell H., Cho N.H., Cummings S.R., Czerwinski S.A., Demuth I., Eckardt R., Eriksson J.G., Ferrucci L., Franco O.H., Froguel P., Gansevoort R.T., Hansen T., Harris T.B., Hastie N., Heliövaara M., Hofman A., Jordan J.M., Jula A., Kähönen M., Kajantie E., Knekt P.B., Koskinen S., Kovacs P., Lehtimäki T., Lind L., Liu Y., Orwoll E.S., Osmond C., Perola M., Pérusse L., Raitakari O.T., Rankinen T., Rao D.C., Rice T.K., Rivadeneira F., Rudan I., Salomaa V., Sørensen T.I., Stumvoll M., Tönjes A., Towne B., Tranah G.J., Tremblay A., Uitterlinden A.G., van der Harst P., Vartiainen E., Viikari J.S., Vitart V., Vohl M.C., Völzke H., Walker M., Wallaschofski H., Wild S., Wilson J.F., Yengo L., Bishop D.T., Borecki I.B., Chambers J.C., Cupples L.A., Dehghan A., Deloukas P., Fatemifar G., Fox C., Furey T.S., Franke L., Han J., Hunter D.J., Karjalainen J., Karpe F., Kaplan R.C., Kooner J.S., McCarthy M.I., Murabito J.M., Morris A.P., Bishop J.A., North K.E., Ohlsson C., Ong K.K., Prokopenko I., Richards J.B., Schadt E.E., Spector T.D., Widén E., Willer C.J., Yang J., Ingelsson E., Mohlke K.L., Hirschhorn J.N., Pospisilik J.A., Zillikens M.C., Lindgren C., Kilpeläinen T.O., Loos R.J.

ISSN

2041-1723 (Electronic)

ISSN-L

2041-1723

Publication state

Published

Issued date

2016

Peer-reviewed

Oui

Volume

Pages

10495

Language

english

Notes

Publication types: Journal Article ; Meta-Analysis ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
Publication Status: epublish

Abstract

To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.

Keywords

Adiposity/genetics, Animals, Drosophila melanogaster/genetics, Drosophila melanogaster/metabolism, Gene Expression Regulation/physiology, Gene Knockdown Techniques, Genetic Predisposition to Disease, Genome-Wide Association Study, Heart Diseases/genetics, Humans, Quantitative Trait Loci/genetics

URN

urn:nbn:ch:serval-BIB_3AD8785589CA5

OAI-PMH

oai:serval.unil.ch:BIB_3AD8785589CA

DOI

10.1038/ncomms10495

Pubmed

26833246

Web of science

000371012200002

Open Access

Yes