Robust regression in biological assay: application to the evaluation of alternative experimental techniques.
Details
Serval ID
serval:BIB_3A130C1B0DF4
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Robust regression in biological assay: application to the evaluation of alternative experimental techniques.
Journal
Experientia
ISSN
0014-4754 (Print)
ISSN-L
0014-4754
Publication state
Published
Issued date
1988
Volume
44
Number
10
Pages
857-873
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
Robust Huber type regression and testing of linear hypotheses are adapted to statistical analysis of parallel line and slope ratio assays. They are applied in the evaluation of results of several experiments carried out in order to compare and validate alternatives to animal experimentation based on embryo and cell cultures. Computational procedures necessary for the application of robust methods of analysis used the conversational statistical package ROBSYS. Special commands for the analysis of parallel line and slope ratio assays have been added to ROBSYS.
Keywords
Animal Testing Alternatives, Animals, Biological Assay, Brain, Caffeine/toxicity, Cells, Cultured, Chick Embryo, Culture Techniques, Embryo, Mammalian, Phenytoin/toxicity, Rats, Regression Analysis, Software, Statistics as Topic
Pubmed
Web of science
Create date
11/09/2011 14:23
Last modification date
20/08/2019 14:29
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