Sexual dimorphism in cancer.

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State: Public
Version: Author's accepted manuscript
Serval ID
serval:BIB_393065D9F168
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Sexual dimorphism in cancer.
Journal
Nature Reviews. Cancer
Author(s)
Clocchiatti A., Cora E., Zhang Y., Dotto G.P.
ISSN
1474-1768 (Electronic)
ISSN-L
1474-175X
Publication state
Published
Issued date
2016
Peer-reviewed
Oui
Volume
16
Number
5
Pages
330-339
Language
english
Abstract
The incidence of many types of cancer arising in organs with non-reproductive functions is significantly higher in male populations than in female populations, with associated differences in survival. Occupational and/or behavioural factors are well-known underlying determinants. However, cellular and molecular differences between the two sexes are also likely to be important. In this Opinion article, we focus on the complex interplay that sex hormones and sex chromosomes can have in intrinsic control of cancer-initiating cell populations, the tumour microenvironment and systemic determinants of cancer development, such as the immune system and metabolism. A better appreciation of these differences between the two sexes could be of substantial value for cancer prevention as well as treatment.
Pubmed
Web of science
Open Access
Yes
Create date
03/05/2016 17:03
Last modification date
20/08/2019 13:28
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