Skin biopsy and I-123 MIBG scintigraphy findings in idiopathic Parkinson's disease and parkinsonism: a comparative study.

Details

Serval ID
serval:BIB_38F11A8F7B7B
Type
Article: article from journal or magazin.
Collection
Publications
Title
Skin biopsy and I-123 MIBG scintigraphy findings in idiopathic Parkinson's disease and parkinsonism: a comparative study.
Journal
Movement disorders
Author(s)
Giannoccaro M.P., Donadio V., Incensi A., Pizza F., Cason E., Di Stasi V., Martinelli P., Scaglione C., Capellari S., Treglia G., Liguori R.
ISSN
1531-8257 (Electronic)
ISSN-L
0885-3185
Publication state
Published
Issued date
06/2015
Peer-reviewed
Oui
Volume
30
Number
7
Pages
986-989
Language
english
Notes
Publication types: Comparative Study ; Journal Article
Publication Status: ppublish
Abstract
(123) I-meta-iodobenzylguanidine ((123) I-MIBG) myocardial scintigraphy is considered reliable in differentiating idiopathic Parkinson's disease (IPD) from other parkinsonisms, but it is biased by pharmacological treatments. Skin biopsy is not influenced by therapy and has disclosed skin denervation in IPD. Our aims were to compare (123) I-MIBG scintigraphy and skin biopsy findings in IPD and parkinsonisms to (1) verify whether myocardial and skin denervations are linked; (2) explore the simultaneous extent of the autonomic dysfunction.
We studied 22 IPD and 11 parkinsonism patients by means of (123) I-MIBG scintigraphy and skin biopsies.
In the IPD group, both (123) I-MIBG scintigraphy and skin biopsy results were abnormal in 91% of patients, showing concordance in 82% of cases. In parkinsonisms, results of both tests were normal in all patients.
(1) Skin biopsy and (123) I-MIBG scintigraphy provide comparable results; (2) in IPD, autonomic dysfunctions are often simultaneously widespread at cardiac and skin branches. © 2015 International Parkinson and Movement Disorder Society.

Keywords
Aged, Autonomic Nervous System Diseases/diagnosis, Autonomic Nervous System Diseases/etiology, Biopsy, Female, Humans, Iodine Radioisotopes, Male, Middle Aged, Myocardial Perfusion Imaging/methods, Parkinson Disease/complications, Parkinson Disease/diagnosis, Parkinsonian Disorders/complications, Parkinsonian Disorders/diagnosis, Skin/innervation, Skin/pathology, 123I-MIBG scintigraphy, Parkinson's disease, Parkinsonism, skin biopsy, small fiber neuropathy
Pubmed
Web of science
Create date
20/08/2017 17:07
Last modification date
20/08/2019 13:28
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