Skin biopsy and I-123 MIBG scintigraphy findings in idiopathic Parkinson's disease and parkinsonism: a comparative study.
Détails
ID Serval
serval:BIB_38F11A8F7B7B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Skin biopsy and I-123 MIBG scintigraphy findings in idiopathic Parkinson's disease and parkinsonism: a comparative study.
Périodique
Movement disorders
ISSN
1531-8257 (Electronic)
ISSN-L
0885-3185
Statut éditorial
Publié
Date de publication
06/2015
Peer-reviewed
Oui
Volume
30
Numéro
7
Pages
986-989
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
(123) I-meta-iodobenzylguanidine ((123) I-MIBG) myocardial scintigraphy is considered reliable in differentiating idiopathic Parkinson's disease (IPD) from other parkinsonisms, but it is biased by pharmacological treatments. Skin biopsy is not influenced by therapy and has disclosed skin denervation in IPD. Our aims were to compare (123) I-MIBG scintigraphy and skin biopsy findings in IPD and parkinsonisms to (1) verify whether myocardial and skin denervations are linked; (2) explore the simultaneous extent of the autonomic dysfunction.
We studied 22 IPD and 11 parkinsonism patients by means of (123) I-MIBG scintigraphy and skin biopsies.
In the IPD group, both (123) I-MIBG scintigraphy and skin biopsy results were abnormal in 91% of patients, showing concordance in 82% of cases. In parkinsonisms, results of both tests were normal in all patients.
(1) Skin biopsy and (123) I-MIBG scintigraphy provide comparable results; (2) in IPD, autonomic dysfunctions are often simultaneously widespread at cardiac and skin branches. © 2015 International Parkinson and Movement Disorder Society.
We studied 22 IPD and 11 parkinsonism patients by means of (123) I-MIBG scintigraphy and skin biopsies.
In the IPD group, both (123) I-MIBG scintigraphy and skin biopsy results were abnormal in 91% of patients, showing concordance in 82% of cases. In parkinsonisms, results of both tests were normal in all patients.
(1) Skin biopsy and (123) I-MIBG scintigraphy provide comparable results; (2) in IPD, autonomic dysfunctions are often simultaneously widespread at cardiac and skin branches. © 2015 International Parkinson and Movement Disorder Society.
Mots-clé
Aged, Autonomic Nervous System Diseases/diagnosis, Autonomic Nervous System Diseases/etiology, Biopsy, Female, Humans, Iodine Radioisotopes, Male, Middle Aged, Myocardial Perfusion Imaging/methods, Parkinson Disease/complications, Parkinson Disease/diagnosis, Parkinsonian Disorders/complications, Parkinsonian Disorders/diagnosis, Skin/innervation, Skin/pathology, 123I-MIBG scintigraphy, Parkinson's disease, Parkinsonism, skin biopsy, small fiber neuropathy
Pubmed
Web of science
Création de la notice
20/08/2017 18:07
Dernière modification de la notice
20/08/2019 14:28