Contribution of connexins to the function of the vascular wall

Details

Ressource 1Download: serval:BIB_36FD7572AFED.P001 (652.12 [Ko])
State: Public
Version: author
License: Not specified
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_36FD7572AFED
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Contribution of connexins to the function of the vascular wall
Journal
Cardiovascular Research
Author(s)
Haefliger  J. A., Nicod  P., Meda  P.
ISSN
0008-6363 (Print)
Publication state
Published
Issued date
05/2004
Volume
62
Number
2
Pages
345-56
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review --- Old month value: May 1
Abstract
Gap junction channels provide an enclosed conduit for direct exchanges of signalling molecules, including ions and small metabolites between cells. This system of communication allows cells to monitor the functional state of their neighbours, and is rapidly modulated to continuously adapt to the immediate needs of groups of coupled cells. In the major arteries, endothelial cells may express three connexins isotypes, namely Connexin 37 (Cx37), Cx40 and Cx43, whereas the underlying smooth muscle cells may express Cx37, Cx40, Cx43 and Cx45. Moreover, myoendothelial gap junctions have also been shown to be involved in the regulation of vascular tone. This review highlights the regulation of vessel connexins in response to injury, as observed during experimental hypertension or wound repair, as well as the consequences of loss of one connexin in different transgenic null mice. In view of the major endocrine role of the kidney in the control of blood pressure, we also discuss the distribution of connexins in the kidney vasculature. Cx40 is present between endothelial cells of vessels and glomeruli, as well as between renin-secreting cells, the modified smooth muscle cells which form the wall of the terminal part of afferent arterioles. Modulation of Cx40 expression in a model of renin-dependent hypertension suggests that this connexin may be implicated in the function of renin-secreting cells. Finally, to address the possible regulation of connexin expression by fluid pressure, we summarize the effects of elevated transmural urine pressure on bladder Cx43 expression.
Keywords
Animals Cell Communication Connexins/*metabolism Endothelium, Vascular/*metabolism Humans Hypertension/*metabolism/physiopathology Ion Channels/*metabolism Kidney/blood supply Muscle, Smooth, Vascular/*metabolism/physiopathology Stress, Mechanical Urinary Bladder/metabolism/physiopathology Wound Healing
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 14:47
Last modification date
25/09/2019 7:08
Usage data