Mechanisms of microRNA deregulation in human cancer.

Details

Serval ID
serval:BIB_3604F78B82ED
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Mechanisms of microRNA deregulation in human cancer.
Journal
Cell Cycle
Author(s)
Deng S., Calin G.A., Croce C.M., Coukos G., Zhang L.
ISSN
1551-4005 (Electronic)
ISSN-L
1551-4005
Publication state
Published
Issued date
2008
Volume
7
Number
17
Pages
2643-2646
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; ReviewPublication Status: ppublish
Abstract
microRNAs (miRNAs) are an abundant class of small non-coding RNAs that function as gene regulators. Although deregulation of miRNA expression is involved in the initiation and progression of tumorigenesis, the underlying mechanisms of miRNA deregulation in human cancer are still largely unknown. Increasing evidence indicates that transcriptional deregulations, epigenetic alterations, mutations, DNA copy number abnormalities and defects in the miRNA biogenesis machinery might contribute to miRNA deregulation in human cancer. A clearer understanding of the mechanisms involved in miRNA deregulation in human cancer will contribute greatly to the development of new miRNA-based strategies in cancer diagnosis and treatment.
Keywords
Epigenesis, Genetic, Gene Dosage, Gene Expression Regulation, Neoplastic, Humans, MicroRNAs/biosynthesis, MicroRNAs/genetics, Neoplasms/genetics, Transcription, Genetic
Pubmed
Create date
14/10/2014 11:43
Last modification date
20/08/2019 13:23
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