Mechanisms of microRNA deregulation in human cancer.

Détails

ID Serval
serval:BIB_3604F78B82ED
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Mechanisms of microRNA deregulation in human cancer.
Périodique
Cell Cycle
Auteur(s)
Deng S., Calin G.A., Croce C.M., Coukos G., Zhang L.
ISSN
1551-4005 (Electronic)
ISSN-L
1551-4005
Statut éditorial
Publié
Date de publication
2008
Volume
7
Numéro
17
Pages
2643-2646
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; ReviewPublication Status: ppublish
Résumé
microRNAs (miRNAs) are an abundant class of small non-coding RNAs that function as gene regulators. Although deregulation of miRNA expression is involved in the initiation and progression of tumorigenesis, the underlying mechanisms of miRNA deregulation in human cancer are still largely unknown. Increasing evidence indicates that transcriptional deregulations, epigenetic alterations, mutations, DNA copy number abnormalities and defects in the miRNA biogenesis machinery might contribute to miRNA deregulation in human cancer. A clearer understanding of the mechanisms involved in miRNA deregulation in human cancer will contribute greatly to the development of new miRNA-based strategies in cancer diagnosis and treatment.
Mots-clé
Epigenesis, Genetic, Gene Dosage, Gene Expression Regulation, Neoplastic, Humans, MicroRNAs/biosynthesis, MicroRNAs/genetics, Neoplasms/genetics, Transcription, Genetic
Pubmed
Création de la notice
14/10/2014 11:43
Dernière modification de la notice
20/08/2019 13:23
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