Compassionate Use of Letermovir in a 2-Year-Old Immunocompromised Child With Resistant Cytomegalovirus Disease.

Details

Serval ID
serval:BIB_34AA25DDD16D
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Compassionate Use of Letermovir in a 2-Year-Old Immunocompromised Child With Resistant Cytomegalovirus Disease.
Journal
Journal of the Pediatric Infectious Diseases Society
Author(s)
Pérez Marín M., Decosterd L.A., Andre P., Buclin T., Mercier T., Murray K., Rizzi M., Meylan P., Jaton-Ogay K., Opota O., Gengler C., Perez M.H., Natterer J., Asner S.A.
ISSN
2048-7207 (Electronic)
ISSN-L
2048-7193
Publication state
Published
Issued date
28/02/2020
Peer-reviewed
Oui
Volume
9
Number
1
Pages
96-99
Language
english
Notes
Publication types: Case Reports ; Journal Article
Publication Status: ppublish
Abstract
Little information on the efficacy and pharmacokinetics of letermovir among immunocompromised children is currently available. We describe here the use of letermovir in a 2-year-old immunocompromised child with ganciclovir-resistant cytomegalovirus disease who required extracorporeal membrane oxygenation. Detailed information on therapeutic-drug-monitoring measures and dosage adjustments for letermovir is provided.
Keywords
Acetates/administration & dosage, Acetates/pharmacokinetics, Acetates/therapeutic use, Antiviral Agents/administration & dosage, Antiviral Agents/pharmacokinetics, Antiviral Agents/therapeutic use, Child, Preschool, Compassionate Use Trials, Cytomegalovirus/genetics, Cytomegalovirus/isolation & purification, Cytomegalovirus Infections/drug therapy, Cytomegalovirus Infections/immunology, Cytomegalovirus Infections/virology, DNA, Viral/blood, Dose-Response Relationship, Drug, Drug Monitoring/methods, Extracorporeal Membrane Oxygenation/adverse effects, Fatal Outcome, Female, Ganciclovir/therapeutic use, Hepatitis, Viral, Human/drug therapy, Hepatitis, Viral, Human/immunology, Humans, Immunocompromised Host, Opportunistic Infections/drug therapy, Pneumonia, Viral/drug therapy, Pneumonia, Viral/immunology, Pneumonia, Viral/virology, Polymerase Chain Reaction, Quinazolines/administration & dosage, Quinazolines/pharmacokinetics, Quinazolines/therapeutic use, Treatment Failure, Viral Load, cytomegalovirus disease, cytomegalovirus infection, letermovir, therapeutic drug monitoring
Pubmed
Web of science
Create date
18/06/2019 9:11
Last modification date
11/08/2021 6:38
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