Immune senescence and vaccination in the elderly.

Details

Serval ID
serval:BIB_332826233AD9
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Immune senescence and vaccination in the elderly.
Journal
Current Topics In Medicinal Chemistry
Author(s)
Lang P.O., Govind S., Bokum A.T., Kenny N., Matas E., Pitts D., Aspinall R.
ISSN
1873-4294 (Electronic)
ISSN-L
1568-0266
Publication state
Published
Issued date
2013
Peer-reviewed
Oui
Volume
13
Number
20
Pages
2541-2550
Language
english
Notes
Publication types: Journal Article ; Review Publication Status: ppublish
Abstract
Vaccines are powerful public health tools that have been of tremendous benefit in protecting vulnerable populations worldwide from many pathogens. However, vaccine- preventable diseases still remain a considerable burden and this is particularly true among aging and aged populations in industrialized countries. The predicted demographic shift in the population landscape towards an ever-increasing aging population and the evidence suggesting that older individuals mount less-than optimal immune response to vaccination have raised the question of improving vaccine responses in older individuals. This review presents recent progress in the understanding at the cellular and molecular levels of age related immune decline and strategies to translate current knowledge into the development of immunization strategies to promote healthy aging, keeping older members of our society autonomous and independent.
Keywords
Aged, Aging/immunology, Humans, Public Health, Vaccination, Vaccines/immunology
Pubmed
Web of science
Create date
15/04/2015 9:03
Last modification date
20/08/2019 13:19
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