Cartilage injury by ramp compression near the gel diffusion rate.

Details

Serval ID
serval:BIB_32972
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Cartilage injury by ramp compression near the gel diffusion rate.
Journal
Journal of Orthopaedic Research
Author(s)
Morel V., Quinn T.M.
ISSN
0736-0266
Publication state
Published
Issued date
2004
Volume
22
Number
1
Pages
145-151
Language
english
Notes
Publication types: In Vitro ; Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Abstract
The mechanics of cartilage injuries have implications for repair strategies. We examined the role of strain rate in cartilage injury under compression near the "gel diffusion" rate (the inherent tissue mechanical relaxation rate). Bovine osteochondral explant disks were subjected to one radially unconfined axial compression at approximately 0.1, 1, 10, 100, or 1000 times the gel diffusion rate to a peak stress of 3.5, 7, or 14 MPa. Effects were monitored in terms of axial strain, changes in water content, superficial cracks, chondrocyte viability, and proteoglycan release. Injury worsened monotonically with peak stress, but varied substantially with strain rate. High strain rates resulted in significant matrix fluid pressurization and impact-like surface cracking with cell death near the superficial zone. Below the gel diffusion rate, cells died throughout the tissue depth during extensive matrix consolidation without cracks. At approximately the gel diffusion rate, no measurable injury occurred, even for peak stresses of 14 MPa and axial compressive strains near 0.8. The gel diffusion rate therefore represented a threshold separating different biomechanical regimes of injury, but at which cartilage was relatively "safe" from injury. Findings may help identify strategies for prevention and treatment of cartilage injury and suggest loading guidelines for tissue engineering.
Keywords
Animals, Cartilage/injuries, Cartilage/physiopathology, Cattle, Compressive Strength, Diffusion, Extracellular Matrix/physiology, Gels, Sprains and Strains/physiopathology, Weight-Bearing
Pubmed
Web of science
Open Access
Yes
Create date
19/11/2007 12:32
Last modification date
20/08/2019 13:18
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