Linking epigenetics to lipid metabolism: focus on histone deacetylases.

Details

Serval ID
serval:BIB_31EEDA562211
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Linking epigenetics to lipid metabolism: focus on histone deacetylases.
Journal
Molecular Membrane Biology
Author(s)
Ferrari A., Fiorino E., Giudici M., Gilardi F., Galmozzi A., Mitro N., Cermenati G., Godio C., Caruso D., De Fabiani E., Crestani M.
ISSN
1464-5203 (Electronic)
ISSN-L
0968-7688
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
29
Number
7
Pages
257-266
Language
english
Abstract
A number of recent studies revealed that epigenetic modifications play a central role in the regulation of lipid and of other metabolic pathways such as cholesterol homeostasis, bile acid synthesis, glucose and energy metabolism. Epigenetics refers to aspects of genome functions regulated in a DNA sequence-independent fashion. Chromatin structure is controlled by epigenetic mechanisms through DNA methylation and histone modifications. The main modifications are histone acetylation and deacetylation on specific lysine residues operated by two different classes of enzymes: Histone acetyltransferases (HATs) and histone deacetylases (HDACs), respectively. The interaction between these enzymes and histones can activate or repress gene transcription: Histone acetylation opens and activates chromatin, while deacetylation of histones and DNA methylation compact chromatin making it transcriptionally silent. The new evidences on the importance of HDACs in the regulation of lipid and other metabolic pathways will open new perspectives in the comprehension of the pathophysiology of metabolic disorders.
Keywords
Lipid metabolism, bile acids, gene regulation, chromatin
Pubmed
Web of science
Create date
28/01/2013 11:26
Last modification date
18/02/2020 6:20
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