Linking epigenetics to lipid metabolism: focus on histone deacetylases.

Détails

ID Serval
serval:BIB_31EEDA562211
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Linking epigenetics to lipid metabolism: focus on histone deacetylases.
Périodique
Molecular Membrane Biology
Auteur(s)
Ferrari A., Fiorino E., Giudici M., Gilardi F., Galmozzi A., Mitro N., Cermenati G., Godio C., Caruso D., De Fabiani E., Crestani M.
ISSN
1464-5203 (Electronic)
ISSN-L
0968-7688
Statut éditorial
Publié
Date de publication
2012
Peer-reviewed
Oui
Volume
29
Numéro
7
Pages
257-266
Langue
anglais
Résumé
A number of recent studies revealed that epigenetic modifications play a central role in the regulation of lipid and of other metabolic pathways such as cholesterol homeostasis, bile acid synthesis, glucose and energy metabolism. Epigenetics refers to aspects of genome functions regulated in a DNA sequence-independent fashion. Chromatin structure is controlled by epigenetic mechanisms through DNA methylation and histone modifications. The main modifications are histone acetylation and deacetylation on specific lysine residues operated by two different classes of enzymes: Histone acetyltransferases (HATs) and histone deacetylases (HDACs), respectively. The interaction between these enzymes and histones can activate or repress gene transcription: Histone acetylation opens and activates chromatin, while deacetylation of histones and DNA methylation compact chromatin making it transcriptionally silent. The new evidences on the importance of HDACs in the regulation of lipid and other metabolic pathways will open new perspectives in the comprehension of the pathophysiology of metabolic disorders.
Mots-clé
Lipid metabolism, bile acids, gene regulation, chromatin
Pubmed
Web of science
Création de la notice
28/01/2013 11:26
Dernière modification de la notice
18/02/2020 6:20
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