Structural insights into PYR/PYL/RCAR ABA receptors and PP2Cs.
Details
Serval ID
serval:BIB_311B8A0FB2D7
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Structural insights into PYR/PYL/RCAR ABA receptors and PP2Cs.
Journal
Plant science
ISSN
1873-2259 (Electronic)
ISSN-L
0168-9452
Publication state
Published
Issued date
01/2012
Peer-reviewed
Oui
Volume
182
Pages
3-11
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Publication Status: ppublish
Abstract
Abscisic acid (ABA) plays an essential function in plant physiology since it is required for biotic and abiotic stress responses as well as control of plant growth and development. A new family of soluble ABA receptors, named PYR/PYL/RCAR, has emerged as ABA sensors able to inhibit the activity of specific protein phosphatases type-2C (PP2Cs) in an ABA-dependent manner. The structural and functional mechanism by which ABA is perceived by these receptors and consequently leads to inhibition of the PP2Cs has been recently elucidated. The module PYR/PYL/RCAR-ABA-PP2C offers an elegant and unprecedented mechanism to control phosphorylation signaling cascades in a ligand-dependent manner. The knowledge of their three-dimensional structures paves the way to the design of ABA agonists able to modulate the plant stress response.
Keywords
Abscisic Acid/chemistry, Abscisic Acid/metabolism, Arabidopsis/metabolism, Arabidopsis Proteins/chemistry, Arabidopsis Proteins/metabolism, Carrier Proteins/chemistry, Carrier Proteins/metabolism, Phosphoprotein Phosphatases/chemistry, Phosphoprotein Phosphatases/metabolism, Plant Growth Regulators/chemistry, Plant Growth Regulators/metabolism, Plant Proteins/chemistry, Plant Proteins/metabolism, Protein Phosphatase 2C, Stress, Physiological, Structure-Activity Relationship
Pubmed
Web of science
Create date
10/01/2019 17:21
Last modification date
21/08/2019 5:35