Insulinoma associated with a case of multiple endocrine neoplasia type I: Functional somatostatin receptors and abnormal glucose-induced insulin secretion.

Details

Serval ID
serval:BIB_30A0E673D19C
Type
Article: article from journal or magazin.
Collection
Publications
Title
Insulinoma associated with a case of multiple endocrine neoplasia type I: Functional somatostatin receptors and abnormal glucose-induced insulin secretion.
Journal
Hormone research
Author(s)
Waeber G., Gomez F., Bishof-Delaloye A., Chaubert P., Francke M.L., Haefliger J.A., Scherrer U., Centeno G., Temler E., Nicod P.
ISSN
0301-0163
Publication state
Published
Issued date
1997
Peer-reviewed
Oui
Volume
48
Number
2
Pages
76-82
Language
english
Notes
Publication types: Case Reports ; Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Abstract
A sporadic case of multiple endocrine neoplasia type I with coexisting insulinoma and hyperparathyroidism was investigated in vivo and in vitro. The insulinoma was localized by somatostatin receptor scintigraphy and these receptors were functionally active. Octreotide administration decreased the basal insulin and glucagon secretion by 90 and 46%, respectively. Immunocytochemistry of the insulinoma tissue was positive for insulin, chromogranin A and neuropeptide Y. The insulinoma cells were also isolated and cultured in vitro. Incubation experiments revealed that a low glucose concentration (1 mmol/l) was sufficient to increase cytosolic free calcium and to produce a maximal glucose-induced insulin release. Northern blot analysis of RNA obtained from the tumor showed a high abundance of the low Km glucose transporter GLUT1 but no transcript for the high Km glucose transporter GLUT2. The abnormal distribution of glucose transporters probably relates to the abnormal glucose sensing of insulinoma cells, and explains their sustained insulin secretion at low glucose concentrations. Whether these abnormalities share a pathogenetic link with the presence of functionally active somatostatin receptors remains to be elucidated.
Keywords
Actins, Adolescent, Dose-Response Relationship, Drug, Follow-Up Studies, Gene Expression Regulation, Neoplastic, Glucagon, Glucose, Glucose Transporter Type 1, Hormones, Humans, Hyperparathyroidism, Immunohistochemistry, Injections, Intravenous, Insulin, Insulinoma, Male, Monosaccharide Transport Proteins, Multiple Endocrine Neoplasia Type 1, Octreotide, Pancreatic Neoplasms, Parathyroid Neoplasms, RNA, Messenger, Receptors, Somatostatin, Tomography, Emission-Computed, Single-Photon
Pubmed
Web of science
Create date
17/11/2008 9:57
Last modification date
20/08/2019 14:15
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