Pneumopathie interstitielle dans la ­polyarthrite rhumatoïde : nouvelles données génétiques et perspectives thérapeutiques [Rheumatoid arthritis-associated interstitial lung disease : new genetic data and therapeutic perspectives]

Details

Serval ID
serval:BIB_3052243319A6
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Pneumopathie interstitielle dans la ­polyarthrite rhumatoïde : nouvelles données génétiques et perspectives thérapeutiques [Rheumatoid arthritis-associated interstitial lung disease : new genetic data and therapeutic perspectives]
Journal
Revue medicale suisse
Author(s)
Valerio F., Daccord C., Letovanec I., Hügle T., Lazor R.
ISSN
1660-9379 (Print)
ISSN-L
1660-9379
Publication state
Published
Issued date
06/03/2019
Peer-reviewed
Oui
Volume
15
Number
641
Pages
536-541
Language
french
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Diffuse interstitial lung disease (ILD) is one of the most frequent extra-articular manifestation of rheumatoid arthritis (RA) and is an important factor of morbidity and mortality. However, the physiopathological mechanisms underlying RA-associated ILD remain poorly understood, and disease management is difficult in the absence of effective treatments and international guidelines. The recent identification of genetic variants and mutations similar to those observed in idiopathic pulmonary fibrosis (IPF), a disease affecting exclusively the lung, provides new insights into the understanding of RA-associated ILD. Furthermore, new antifibrotic drugs approved for the treatment of IPF, including pirfenidone and nintedanib, could also prove to be effective for RA-associated ILD. Studies are ongoing to confirm this hypothesis.
Keywords
Arthritis, Rheumatoid/complications, Arthritis, Rheumatoid/genetics, Arthritis, Rheumatoid/therapy, Humans, Idiopathic Pulmonary Fibrosis/genetics, Idiopathic Pulmonary Fibrosis/therapy, Lung Diseases, Interstitial/genetics, Lung Diseases, Interstitial/therapy, Treatment Outcome
Pubmed
Create date
12/03/2019 16:03
Last modification date
20/08/2019 14:15
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