Pictures of focal nodular hyperplasia and hepatocellular adenomas.

Details

Serval ID
serval:BIB_303A656EFFD9
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Pictures of focal nodular hyperplasia and hepatocellular adenomas.
Journal
World Journal of Hepatology
Author(s)
Sempoux C., Balabaud C., Bioulac-Sage P.
ISSN
1948-5182 (Electronic)
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
6
Number
8
Pages
580-595
Language
english
Notes
Publication types: Journal Article ; Review Publication Status: ppublish
Abstract
This practical atlas aims to help liver and non liver pathologists to recognize benign hepatocellular nodules on resected specimen. Macroscopic and microscopic views together with immunohistochemical stains illustrate typical and atypical aspects of focal nodular hyperplasia and of hepatocellular adenoma, including hepatocellular adenomas subtypes with references to clinical and imaging data. Each step is important to make a correct diagnosis. The specimen including the nodule and the non-tumoral liver should be sliced, photographed and all different looking areas adequately sampled for paraffin inclusion. Routine histology includes HE, trichrome and cytokeratin 7. Immunohistochemistry includes glutamine synthase and according to the above results additional markers such as liver fatty acid binding protein, C reactive protein and beta catenin may be realized to differentiate focal nodular hyperplasia from hepatocellular adenoma subtypes. Clues for differential diagnosis and pitfalls are explained and illustrated.
Pubmed
Open Access
Yes
Create date
16/01/2015 13:07
Last modification date
20/08/2019 14:14
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