On the Host Side of the Hepatitis E Virus Life Cycle.

Details

Serval ID
serval:BIB_2FFD9F83A168
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
On the Host Side of the Hepatitis E Virus Life Cycle.
Journal
Cells
Author(s)
Oechslin N., Moradpour D., Gouttenoire J.
ISSN
2073-4409 (Electronic)
ISSN-L
2073-4409
Publication state
Published
Issued date
22/05/2020
Peer-reviewed
Oui
Volume
9
Number
5
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
Hepatitis E virus (HEV) infection is one of the most common causes of acute hepatitis in the world. HEV is an enterically transmitted positive-strand RNA virus found as a non-enveloped particle in bile as well as stool and as a quasi-enveloped particle in blood. Current understanding of the molecular mechanisms and host factors involved in productive HEV infection is incomplete, but recently developed model systems have facilitated rapid progress in this area. Here, we provide an overview of the HEV life cycle with a focus on the host factors required for viral entry, RNA replication, assembly and release. Further developments of HEV model systems and novel technologies should yield a broader picture in the future.
Keywords
HEV, host factor, particle production, viral replication, virus entry
Pubmed
Open Access
Yes
Create date
10/06/2020 21:41
Last modification date
15/09/2020 5:26
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