Therapeutic drug monitoring of targeted anticancer therapy.

Details

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State: Public
Version: Final published version
Serval ID
serval:BIB_2E88575DAD1C
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Therapeutic drug monitoring of targeted anticancer therapy.
Journal
Biomarkers In Medicine
Author(s)
Decosterd L.A., Widmer N., Zaman K., Cardoso E., Buclin T., Csajka C.
ISSN
1752-0371 (Electronic)
ISSN-L
1752-0363
Publication state
Published
Issued date
09/2015
Peer-reviewed
Oui
Volume
9
Number
9
Pages
887-893
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
New oral targeted anticancer therapies are revolutionizing cancer treatment by transforming previously deadly malignancies into chronically manageable conditions. Nevertheless, drug resistance, persistence of cancer stem cells, and adverse drug effects still limit their ability to stabilize or cure malignant diseases in the long term. Response to targeted anticancer therapy is influenced by tumor genetics and by variability in drug concentrations. However, despite a significant inter-patient pharmacokinetic variability, targeted anticancer drugs are essentially licensed at fixed doses. Their therapeutic use could however be optimized by individualization of their dosage, based on blood concentration measurements via the therapeutic drug monitoring (TDM). TDM can increase the probability of therapeutic responses to targeted anticancer therapies, and would help minimize the risk of major adverse reactions.
Keywords
Antineoplastic Agents/pharmacokinetics, Antineoplastic Agents/pharmacology, Drug Monitoring/methods, Humans, Molecular Targeted Therapy/methods, Neoplasms/drug therapy, Neoplasms/metabolism
Pubmed
Web of science
Create date
17/09/2015 8:52
Last modification date
20/08/2019 13:13
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