How to Recruit the Correct RNA Polymerase? Lessons from snRNA Genes.

Details

Serval ID
serval:BIB_2D60ACFF38B5
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
How to Recruit the Correct RNA Polymerase? Lessons from snRNA Genes.
Journal
Trends in Genetics
Author(s)
Dergai O., Hernandez N.
ISSN
0168-9525 (Print)
ISSN-L
0168-9525
Publication state
Published
Issued date
06/2019
Peer-reviewed
Oui
Volume
35
Number
6
Pages
457-469
Language
english
Abstract
Nuclear eukaryotic genomes are transcribed by three related RNA polymerases (Pol), which transcribe distinct gene sets. Specific Pol recruitment is achieved through selective core promoter recognition by basal transcription factors (TFs). Transcription by an inappropriate Pol appears to be rare and to generate mostly unstable products. A collection of short noncoding RNA genes [for example, small nuclear RNA (snRNA) or 7SK RNA genes], which play essential roles in processes such as maturation of RNA molecules or control of Pol II transcription elongation, possess highly similar core promoters, and yet are transcribed for some by Pol II and for others by Pol III as a result of small promoter differences. Here we discuss the mechanisms of selective Pol recruitment to such promoters.
Keywords
RNA polymerase, SNAPc, snRNA genes, transcription initiation
Pubmed
Web of science
Create date
06/05/2019 17:09
Last modification date
20/08/2019 14:12
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