Validation of the revised international prognostic scoring system (IPSS-R) in patients with myelodysplastic syndrome: a multicenter study.
Details
Serval ID
serval:BIB_2CC848AADF0C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Validation of the revised international prognostic scoring system (IPSS-R) in patients with myelodysplastic syndrome: a multicenter study.
Journal
Leukemia Research
ISSN
1873-5835 (Electronic)
ISSN-L
0145-2126
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
38
Number
1
Pages
57-64
Language
english
Notes
Publication types: Journal Article ; Multicenter Study ; Validation StudiesPublication Status: ppublish
Abstract
The revised IPSS (IPSS-R) was developed aiming at a better prognostication, taking into account patients treated with best supportive care. We herein validated this model on the basis of data from 1314 patients who received BSC only as well as patients who underwent induction chemotherapy (n=214) or allogeneic transplantation (n=167). We could demonstrate a clear distinction of the IPSS-R risk categories with regard to survival and risk of AML evolution in all patient cohorts. When comparing IPSS-R, IPSS, WHO prognostic scoring system (WPSS) and Duesseldorf score, the best results regarding the ability to predict survival were obtained by the IPSS-R.
Keywords
Acute Disease, Adolescent, Adult, Aged, Aged, 80 and over, Disease Progression, Female, Humans, Leukemia, Myeloid/pathology, Leukemia, Myeloid/therapy, Male, Middle Aged, Multivariate Analysis, Myelodysplastic Syndromes/pathology, Myelodysplastic Syndromes/therapy, Prognosis, Reproducibility of Results, Risk Assessment/methods, Risk Factors, Survival Analysis, Young Adult
Pubmed
Web of science
Create date
18/10/2016 15:13
Last modification date
20/08/2019 14:11
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