Degenerescence programmee de maladies musculaires: aspects moleculaires et previsions therapeutiques. [Mechanisms leading to muscle degeneration: molecular mechanisms and therapeutical forecasts]

Details

Serval ID
serval:BIB_2A4E808CFB3C
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Degenerescence programmee de maladies musculaires: aspects moleculaires et previsions therapeutiques. [Mechanisms leading to muscle degeneration: molecular mechanisms and therapeutical forecasts]
Journal
Revue Médicale Suisse
Author(s)
Kuntzer  T., Bader  C. R., Sinnreich  M.
ISSN
1660-9379 (Print)
Publication state
Published
Issued date
05/2006
Peer-reviewed
Oui
Volume
2
Number
64
Pages
1174-7
Notes
English Abstract Journal Article Review --- Old month value: May 3
Abstract
In inclusion body myositis (IBM), there is muscular amyloidogenesis and inflammation. A related disorder is due to alterations in the ubiquitin pathway involving the valsolin-containing protein leading to IBM, dementia and Paget's disease. Alteration in the dystrophin glycoprotein complex leads to several muscular dystrophies (MD), and the pathogenesis of dystrophin related MD as well as certain limb girdle MD are discussed. Therapeutic strategies involving inhibition of proteolytic cascades as well as inhibition of a negative regulator of muscle growth (myostatin) are briefly introduced. Finally, molecular aspects of the most common form of adult myopathy, myotonic MD, are discussed. This disease is caused by an aberrant splicing mechanism and interference thereof may be useful in designing therapeutic strategies.
Keywords
Humans Muscular Dystrophies/*drug therapy/*genetics Myositis, Inclusion Body/*drug therapy/*genetics
Pubmed
Create date
25/01/2008 12:43
Last modification date
20/08/2019 13:09
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