The central region of human immunodeficiency virus type 1 p6 protein (Gag residues S14-I31) is dispensable for the virus in vitro
Details
Serval ID
serval:BIB_29E1293D2858
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The central region of human immunodeficiency virus type 1 p6 protein (Gag residues S14-I31) is dispensable for the virus in vitro
Journal
Journal of General Virology
ISSN
0022-1317 (Print)
Publication state
Published
Issued date
04/2004
Volume
85
Number
Pt 4
Pages
921-7
Notes
In Vitro
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Apr
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Apr
Abstract
The human immunodeficiency virus type 1 p6 region encodes p6(Gag) and the transframe p6(Pol) protein. The Gag frame encodes an N-terminal late assembly L domain and a C-terminal Vpr binding domain. In the Pol frame, substitution at a C-terminal motif decreases protease autocleavage. The role of the highly polymorphic central region of p6, comprising amino acids S14-I31 (p6(Gag)) and R20-D39 (p6(Pol)), is unclear. Analysis of this central region demonstrated that 35 % of p6(Gag) appears to be dispensable for virus propagation in vitro and smaller deletion and insertion polymorphisms can be tolerated in vivo. Extensive Pol deletion (deltaR20-D39, 42 % of p6(Pol)) did not alter protease autocleavage.
Keywords
Amino Acid Sequence
Gene Products, gag/chemistry/*genetics/*physiology
Gene Products, pol/chemistry/genetics/physiology
HIV Infections/virology
HIV-1/*genetics/isolation & purification/pathogenicity/*physiology
Humans
Molecular Sequence Data
Phenotype
Polymorphism, Genetic
Recombination, Genetic
Sequence Deletion
Virulence/genetics/physiology
Virus Replication/genetics/physiology
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 14:45
Last modification date
20/08/2019 13:09