Depletion of Gram-Positive Bacteria Impacts Hepatic Biological Functions During the Light Phase.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_288D9DD0B3BE
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Depletion of Gram-Positive Bacteria Impacts Hepatic Biological Functions During the Light Phase.
Journal
International journal of molecular sciences
Author(s)
Oh HYP, Ellero-Simatos S., Manickam R., Tan N.S., Guillou H., Wahli W.
ISSN
1422-0067 (Electronic)
ISSN-L
1422-0067
Publication state
Published
Issued date
14/02/2019
Peer-reviewed
Oui
Volume
20
Number
4
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Living organisms display internal biological rhythms, which are an evolutionarily conserved adaptation to the environment that drives their rhythmic behavioral and physiological activities. The gut microbiota has been proposed, in association with diet, to regulate the intestinal peripheral clock. However, the effect of gut dysbiosis on liver remains elusive, despite that germfree mice show alterations in liver metabolic functions and the hepatic daily rhythm. We analyzed whether the disruption of gut microbial populations with various antibiotics would differentially impact liver functions in mice. Our results support the notion of an impact on the hepatic biological rhythm by gram-positive bacteria. In addition, we provide evidence for differential roles of gut microbiota spectra in xenobiotic metabolism that could protect against the harmful pharmacological effects of drugs. Our results underscore a possible link between liver cell proliferation and gram-positive bacteria.
Keywords
Animals, Cell Proliferation/drug effects, Circadian Clocks/genetics, Dysbiosis/drug therapy, Dysbiosis/genetics, Dysbiosis/physiopathology, Gastrointestinal Microbiome/genetics, Gastrointestinal Microbiome/physiology, Gram-Positive Bacteria/genetics, Gram-Positive Bacteria/physiology, Humans, Intestines/microbiology, Intestines/physiology, Liver/drug effects, Liver/microbiology, Liver/physiology, Mice, antibiotics, circadian rhythm, gene expression, gut microbiota, liver
Pubmed
Web of science
Open Access
Yes
Create date
31/03/2019 15:23
Last modification date
20/08/2019 14:08
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