Automated lung vessel segmentation reveals blood vessel volume redistribution in viral pneumonia.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_2701A13D3582
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Automated lung vessel segmentation reveals blood vessel volume redistribution in viral pneumonia.
Journal
European journal of radiology
Author(s)
Poletti J., Bach M., Yang S., Sexauer R., Stieltjes B., Rotzinger D.C., Bremerich J., Walter Sauter A., Weikert T.
ISSN
1872-7727 (Electronic)
ISSN-L
0720-048X
Publication state
Published
Issued date
17/03/2022
Peer-reviewed
Oui
Volume
150
Pages
110259
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Abstract
It is known from histology studies that lung vessels are affected in viral pneumonia. However, their diagnostic potential as a chest CT imaging parameter has only rarely been exploited. The purpose of this study is to develop a robust method for automated lung vessel segmentation and morphology analysis and apply it to a large chest CT dataset.
In total, 509 non-enhanced chest CTs (NECTs) and 563 CT pulmonary angiograms (CTPAs) were included. Sub-groups were patients with healthy lungs (group_NORM, n = 634) and those RT-PCR-positive for Influenza A/B (group_INF, n = 159) and SARS-CoV-2 (group_COV, n = 279). A lung vessel segmentation algorithm (LVSA) based on traditional image processing was developed, validated with a point-of-interest approach, and applied to a large clinical dataset. Total blood vessel volume in lung (TBV) and the blood vessel volume percentage (BV%) of three blood vessel size types were calculated and compared between groups: small (BV5%, cross-sectional area < 5 mm <sup>2</sup> ), medium (BV5-10%, 5-10 mm <sup>2</sup> ) and large (BV10%, >10 mm <sup>2</sup> ).
Sensitivity of the LVSA was 84.6% (95 %CI: 73.9-95.3) for NECTs and 92.8% (95 %CI: 90.8-94.7) for CTPAs. In viral pneumonia, besides an increased TBV, the main finding was a significantly decreased BV5% in group_COV (n = 14%) and group_INF (n = 15%) compared to group_NORM (n = 18%) [p < 0.001]. At the same time, BV10% was increased (group_COV n = 15% and group_INF n = 14% vs. group_NORM n = 11%; p < 0.001).
In COVID-19 and Influenza, the blood vessel volume is redistributed from small to large vessels in the lung. Automated LSVA allows researchers and clinicians to derive imaging parameters for large amounts of CTs. This can enhance the understanding of vascular changes, particularly in infectious lung diseases.
Keywords
Algorithms, Blood vessels, COVID-19, Influenza, Viral pneumonia
Pubmed
Open Access
Yes
Create date
29/03/2022 12:47
Last modification date
30/03/2022 7:08
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