Effect of increasing heart rate in patients with aortic regurgitation. Effect of incremental atrial pacing on scintigraphic, hemodynamic and thermodilution measurements

Details

Serval ID
serval:BIB_2691D58D350D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Effect of increasing heart rate in patients with aortic regurgitation. Effect of incremental atrial pacing on scintigraphic, hemodynamic and thermodilution measurements
Journal
American Journal of Cardiology
Author(s)
Firth  B. G., Dehmer  G. J., Nicod  P., Willerson  J. T., Hillis  L. D.
ISSN
0002-9149 (Print)
Publication state
Published
Issued date
06/1982
Volume
49
Number
8
Pages
1860-7
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Jun
Abstract
This study was performed to assess the effect of pacing-induced tachycardia in patients with aortic regurgitation. In 12 patients (5 men and 7 women with a mean age of 53 years) with aortic regurgitation, left ventricular end-diastolic and end-systolic volume indexes were measured with multigated equilibrium blood pool imaging, and forward cardiac index was determined with thermodilution, both at rest (mean heart rate +/- standard deviation 72 +/- 8 beats/min) and during atrial pacing at 100 and 120 beats/min. Pacing caused a decremental reduction in left ventricular end-diastolic and end-systolic volume indexes and radionuclide-determined stroke volume index but no change in radionuclide-determined cardiac index or left ventricular ejection fraction. Forward cardiac index increased incrementally from the baseline value at rest to that at 120 beats/min despite a decremental reduction in stroke volume index. There was a stepwise decrease in regurgitant volume/stroke (46 +/- 20 ml/m2 at baseline, 27 +/- 15 at 120 beats/min; p less than 0.05) but no change in regurgitant volume/min (3.38 +/- 1.80 liters/min per m2 at baseline, 3.22 +/- 1.78 at 120 beats/min; difference not significant [NS]) or regurgitant fraction (0.54 +/- 0.13 at baseline, 0.49 +/- 0.13 at 120 beats/min; NS). Mean femoral arterial, pulmonary arterial and pulmonary capillary wedge pressures did not change with pacing.
Keywords
Aortic Valve Insufficiency/diagnosis/*physiopathology Blood Pressure Cardiac Output *Cardiac Pacing, Artificial Erythrocytes Female Heart/radionuclide imaging Heart Catheterization Heart Rate Humans Male Middle Aged Sodium Pertechnetate Tc 99m Stroke Volume Technetium/diagnostic use Thermodilution
Pubmed
Web of science
Create date
25/01/2008 14:00
Last modification date
20/08/2019 13:05
Usage data