Evoked axonal oxytocin release in the central amygdala attenuates fear response.

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State: Public
Version: author
Serval ID
serval:BIB_260A349557CD
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Evoked axonal oxytocin release in the central amygdala attenuates fear response.
Journal
Neuron
Author(s)
Knobloch H.S., Charlet A., Hoffmann L.C., Eliava M., Khrulev S., Cetin A.H., Osten P., Schwarz M.K., Seeburg P.H., Stoop R., Grinevich V.
ISSN
1097-4199 (Electronic)
ISSN-L
0896-6273
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
73
Number
3
Pages
553-566
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
The hypothalamic neuropeptide oxytocin (OT), which controls childbirth and lactation, receives increasing attention for its effects on social behaviors, but how it reaches central brain regions is still unclear. Here we gained by recombinant viruses selective genetic access to hypothalamic OT neurons to study their connectivity and control their activity by optogenetic means. We found axons of hypothalamic OT neurons in the majority of forebrain regions, including the central amygdala (CeA), a structure critically involved in OT-mediated fear suppression. In vitro, exposure to blue light of channelrhodopsin-2-expressing OT axons activated a local GABAergic circuit that inhibited neurons in the output region of the CeA. Remarkably, in vivo, local blue-light-induced endogenous OT release robustly decreased freezing responses in fear-conditioned rats. Our results thus show widespread central projections of hypothalamic OT neurons and demonstrate that OT release from local axonal endings can specifically control region-associated behaviors.
Pubmed
Web of science
Open Access
Yes
Create date
06/03/2012 20:22
Last modification date
20/08/2019 14:04
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