Granules of cytolytic T-lymphocytes contain two serine esterases

Details

Serval ID
serval:BIB_2432274EC8EB
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Granules of cytolytic T-lymphocytes contain two serine esterases
Journal
EMBO Journal
Author(s)
Masson  D., Nabholz  M., Estrade  C., Tschopp  J.
ISSN
0261-4189 (Print)
Publication state
Published
Issued date
07/1986
Volume
5
Number
7
Pages
1595-1600
Notes
Journal Article Research Support, Non-U.S. Gov't --- Old month value: Jul
Abstract
Cytoplasmic granules from cytolytic T-lymphocytes (CTL) contain two proteins which react with the serine esterase-specific affinity label diisopropylfluorophosphate (DFP). One of these is a trypsin-like esterase which consists of two disulfide-linked 35-kd subunits. The other consists of a single 29-kd chain. Both molecules are induced concomitantly with cytolytic activity and perforin activity in a CTL-derived T-cell hybrid.
Keywords
Animals Cell Line Cytoplasmic Granules/*enzymology Esterases/isolation & purification/*metabolism Hemolysis Hydrogen-Ion Concentration Isoflurophate/pharmacology Kinetics Mice T-Lymphocytes, Cytotoxic/*immunology
Pubmed
Web of science
Create date
24/01/2008 15:18
Last modification date
20/08/2019 13:02
Usage data