Circadian regulation of renal function.

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Version: Author's accepted manuscript
Serval ID
serval:BIB_24002A6EAB19
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Circadian regulation of renal function.
Journal
Kidney International
Author(s)
Firsov D., Bonny O.
ISSN
1523-1755[electronic], 0085-2538[linking]
Publication state
Published
Issued date
2010
Volume
78
Number
7
Pages
640-645
Language
english
Abstract
Urinary excretion of water and all major electrolytes exhibit robust circadian oscillations. The 24-h periodicity has been well documented for several important determinants of urine formation, including renal blood flow, glomerular filtration, tubular reabsorption, and tubular secretion. Disturbance of the renal circadian rhythms is increasingly recognized as a risk factor for hypertension, polyuria, and other diseases and may contribute to renal fibrosis. The origin of these rhythms has been attributed to the reactive response of the kidney to circadian changes in volume and/or in the composition of extracellular fluids that are entrained by rest/activity and feeding/fasting cycles. However, numerous studies have shown that most of the renal excretory rhythms persist for long periods of time, even in the absence of periodic environmental cues. These observations led to the hypothesis of the existence of a self-sustained mechanism, enabling the kidney to anticipate various predictable circadian challenges to homeostasis. The molecular basis of this mechanism remained unknown until the recent discovery of the mammalian circadian clock made of a system of autoregulatory transcriptional/translational feedback loops, which have been found in all tissues studied, including the kidney. Here, we present a review of the growing evidence showing the involvement of the molecular clock in the generation of renal excretory rhythms.
Keywords
circadian rhythm, glomerular filtration, tubular reabsorption/secretion, water-electrolyte balance, parathyroid-hormone 1-34, arginine-vasopressin, postmenopausal women, phosphate excretion, nocturnal polyuria, diurnal-variation, stone formers, human-serum, shift work, rhythm
Pubmed
Web of science
Open Access
Yes
Create date
13/10/2010 13:40
Last modification date
20/10/2020 14:41
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