Intervention du système calcium-calmoduline dans la libération de l'hormone de croissance provoquée par la somatocrinine [Intervention of the calcium-calmodulin system in the release of growth hormone induced by somatocrinin]

Details

Serval ID
serval:BIB_2349A757032A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Intervention du système calcium-calmoduline dans la libération de l'hormone de croissance provoquée par la somatocrinine [Intervention of the calcium-calmodulin system in the release of growth hormone induced by somatocrinin]
Journal
Annales d'Endocrinologie
Author(s)
Mougin C., Kehrer P., Gaillard R.
ISSN
0003-4266
Publication state
Published
Issued date
1985
Peer-reviewed
Oui
Volume
46
Number
1
Pages
61-63
Language
french
Abstract
This study was carried out to evaluate the role of the calcium-calmodulin system in cellular mediation of somatocrinin action by cells producing growth hormone. We compared GH release to intra- and extracellular cAMP levels, after incubation of pituitary cells in monolayer culture with somatocrinin alone or somatocrinin associated with exogenous calmodulin, or specific calmodulin inhibitor (W13). Calmodulin (10(-6) M) decreases somatocrinin - induced cAMP levels, maintaining elevated GH levels. W13 (10(-5) M) increases somatocrinin - induced cAMP and GH levels. Thus GH release induced by somatocrinin is modulated by two interrelated systems, adenylcyclase - cAMP system and Ca++-calmodulin system.
Keywords
Animals, Calcium/physiology, Calmodulin/physiology, Cells, Cultured, Cyclic AMP/metabolism, Female, Growth Hormone/metabolism, Growth Hormone-Releasing Hormone/pharmacology, Peptide Fragments/pharmacology, Pituitary Gland, Anterior/drug effects, Pituitary Gland, Anterior/metabolism, Rats, Rats, Inbred Strains, Sulfonamides/pharmacology
Pubmed
Web of science
Create date
15/02/2008 16:57
Last modification date
20/08/2019 13:00
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