Adenosine increases an internal calcium store in the smooth muscle of guinea-pig taenia coli

Details

Serval ID
serval:BIB_22F01BD82306
Type
Article: article from journal or magazin.
Collection
Publications
Title
Adenosine increases an internal calcium store in the smooth muscle of guinea-pig taenia coli
Journal
European Journal of Pharmacology
Author(s)
Frischknecht  R., Ferrero  J. D.
ISSN
0014-2999 (Print)
Publication state
Published
Issued date
03/1985
Peer-reviewed
Oui
Volume
110
Number
1
Pages
109-12
Notes
In Vitro Journal Article Research Support, Non-U.S. Gov't --- Old month value: Mar 26
Abstract
The effect of adenosine on an internal calcium store which can be released by carbachol to produce a transient contraction in Ca2+-free solution was investigated in the taenia depolarized by high K+. The carbachol contraction in Ca2+-free solution was increased by the preceding application of adenosine (3 X 10(-5) to 10(-3) M), an effect which was mimicked by ATP, but not by the slowly degradable analog alpha, beta-methylene ATP. The P1-purinoceptor antagonist 8-phenyltheophylline inhibited the increase caused by adenosine without modifying the carbachol contraction in controls. It is concluded that stimulation of an extracellular P1-purinoceptor increases an internal store of calcium, which might contribute to the relaxation induced by adenosine in the taenia.
Keywords
Adenosine/*pharmacology Adenosine Triphosphate/pharmacology Animals Calcium/*metabolism Egtazic Acid/pharmacology Female Guinea Pigs Intestines/*drug effects/metabolism Male Muscle Contraction/drug effects Muscle, Smooth/*drug effects/metabolism/physiology Receptors, Neurotransmitter/drug effects Receptors, Purinergic
Pubmed
Web of science
Create date
25/01/2008 8:34
Last modification date
20/08/2019 13:00
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