Strategy to tether organometallic ruthenium-arene anticancer compounds to recombinant human serum albumin

Details

Serval ID
serval:BIB_22284FAB6138
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Strategy to tether organometallic ruthenium-arene anticancer compounds to recombinant human serum albumin
Journal
Inorganic chemistry
Author(s)
Ang  W. H., Daldini  E., Juillerat-Jeanneret  L., Dyson  P. J.
ISSN
0020-1669 (Print)
Publication state
Published
Issued date
2007
Volume
46
Number
22
Pages
9048-9050
Notes
PT - Journal Article PT - Research Support, Non-U.S. Gov't
Abstract
In order to utilize macromolecules for drug targeting and delivery, a strategy to tether organometallic ruthenium-arene drugs to carrier protein molecules was developed. The approach involves the design of a drug fragment capable of conjugating to linker molecules on a modified carrier protein via hydrazone bond formation. The proof-of-concept using recombinant human serum albumin is described
Keywords
Antineoplastic Agents/chemistry/Humans/Organometallic Compounds/Proteins/Recombinant Proteins/Research/Ruthenium/Science/Serum Albumin/Switzerland
Pubmed
Web of science
Create date
29/01/2008 18:36
Last modification date
20/08/2019 12:59
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