The coupling of low-level auditory dysfunction and oxidative stress in psychosis patients.

Details

Ressource 1Download: 28189532_AM.pdf (2129.47 [Ko])
State: Public
Version: Author's accepted manuscript
Serval ID
serval:BIB_22245425C64D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The coupling of low-level auditory dysfunction and oxidative stress in psychosis patients.
Journal
Schizophrenia research
Author(s)
Geiser E., Retsa C., Knebel J.F., Ferrari C., Jenni R., Fournier M., Alameda L., Baumann P.S., Clarke S., Conus P., Do K.Q., Murray M.M.
ISSN
1573-2509 (Electronic)
ISSN-L
0920-9964
Publication state
Published
Issued date
12/2017
Peer-reviewed
Oui
Volume
190
Pages
52-59
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Patients diagnosed with schizophrenia often present with low-level sensory deficits. It is an open question whether there is a functional link between these deficits and the pathophysiology of the disease, e.g. oxidative stress and glutathione (GSH) metabolism dysregulation. Auditory evoked potentials (AEPs) were recorded from 21 psychosis disorder patients and 30 healthy controls performing an active, auditory oddball task. AEPs to standard sounds were analyzed within an electrical neuroimaging framework. A peripheral measure of participants' redox balance, the ratio of glutathione peroxidase and glutathione reductase activities (GPx/GR), was correlated with the AEP data. Patients displayed significantly decreased AEPs over the time window of the P50/N100 complex resulting from significantly weaker responses in the left temporo-parietal lobe. The GPx/GR ratio significantly correlated with patients' brain activity during the time window of the P50/N100 in the medial frontal lobe. We show for the first time a direct coupling between electrophysiological indices of AEPs and peripheral redox dysregulation in psychosis patients. This coupling is limited to stages of auditory processing that are impaired relative to healthy controls and suggests a link between biochemical and sensory dysfunction. The data highlight the potential of low-level sensory processing as a trait-marker of psychosis.

Keywords
Auditory, Event-related potential (ERP), Glutathione (GSH), Oxidative stress, Psychosis, Schizophrenia
Pubmed
Web of science
Open Access
Yes
Create date
21/02/2017 15:33
Last modification date
20/08/2019 13:59
Usage data